Text

E-book Xenopus : From Basic Biology to Disease Models in the Genomic Era

---

Penilaian

---

Frogs have played so central a role in biological research that many people’s only memory of actual biological study involves dissecting one in high school. It’s no surprise, then, that frogs have been central to scientifc discovery for centuries. Marcello Malpighi had at least an inkling of the concept we now call “model organisms.” He repeatedly extolled the frog as an out-standing system for study, and it was in a frog that he f rst dis-covered capillaries of the circulatory system in 1661 (Holmes, 1993; West, 2013). He even wrote to his friend Giovanni Borelli that “indeed, things show up much more clearly in frogs” (Boorstin, 1985). Likewise, the entire feld of electrophysiol-ogy is frequently considered to have originated with Galvani’s experiments on frog legs in 1791 (Piccolino, 1997 ). The frog’s external development is another boon, one that was exploited by embryologists at least since 1758, when Johann Rösel von Rosenhof engraved the f rst chronological depictions of eggs developing into tadpoles and then into frogs (Wellmann, 2017). In 1886, nuclear transplantation in frogs and toads would frst be attempted in an exploration of the hereditary control of development (Rauber, 1886), presaging Nobel prize-winning work on nuclear totipotency nearly another century later. In the late 19th century, newts and salamanders became the favored amphibian for embry-ologists (Beetschen, 2004), but beginning in the mid-20th century, a curious foray into endocrinology in South Africa led to the rise of Xenopus frogs as the dominant amphibian for laboratory studies of biology across the world. Since that time, Xenopus was used for discoveries as varied as the frst description of nuclear pores, to the f rst isolation of a eukaryotic gene, to the demonstration of the totipotence of nuclei, to the invention of in situ hybridiza-tion. Several excellent historical memoirs of research on Xenopus have been published previously, but each has a more specifc focus on discrete elements of our frog’s suc-cess (Blow and Laskey, 2016; Brown, 2004; Deuchar, 1975b; Gurdon and Hopwood, 2000; Maller, 2012). My goal here is to provide a more general history of research with Xenopus. I will cover the period spanning the frst description of the genus in 1803 through about 1980, when work with Xenopus exploded, establishing the vibrant model organism that we use today. I hope the chapter will provide an entertaining journey back in time for the Xenopus community, my scien-tifc family for over 30 years.

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

576 ABU x

Penerbit

London : Taylor & Francis., 2022

Deskripsi Fisik

361 hlm

Bahasa

English

ISBN/ISSN

9781003050230

Klasifikasi

576

Tipe Isi

text

Tipe Media

computer

Tipe Pembawa

online resource

Edisi

-

Subjek

Genetics

Info Detail Spesifik

-

Pernyataan Tanggungjawab

-

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar