Text
E-book Nanofibres in Drug Delivery
This volume concerns the potential of drug- loaded polymer nanofibres in pharmaceutics. It is designed to act as a primer for those about to start research in this area, be they new MSc or PhD students or more experienced researchers looking to move into the field. It places significant emphasis on the experimental aspects of fibre production, and provides hints and tips based on the authors’ experience throughout to guide readers as they initiate their own experiments. The book can be read as a whole to give a detailed background on pharmaceutical nanofibres, with both experimental insight and an in- depth survey of the key results to emerge from the significant body of literature in this area. Alternatively, it may act as a reference volume to be consulted when embarking on a new series of experiments.We will begin in this chapter with a brief introduction to the key concepts in pharmaceutical science with which the reader is likely to need to be familiar, including key notions in drug delivery and methods of materials characterisation. In subsequent chapters we will discuss the methods by which nanofibres can be produced, and review some of the most exciting results from this field of research. Continuous nanofibrous mats have very high surface- area- to- volume ratios and offer the advantage of very high porosity, typically ranging between 50% and 99%. By controlling the spinning process, systems with a wide range of fibre size and porosity characteristics can be produced, yielding materials with multiple functionalities. Fibres can be prepared as monolithic systems, where the fibre composition is the same throughout, as core/ shell systems with different interior and exterior compartments, or with more exotic multi- component architectures. These properties have caused them to be much explored in the drug delivery setting, as will be discussed subsequently in this volume. Fibres can be prepared from a wide variety of materials, but in the drug delivery context they typically comprise a filament- forming polymer carrier loaded with a drug.
Tidak tersedia versi lain