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E-book Prototype of a Biomimetic Multi-Spiked Connecting Scaffold

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Penilaian

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The aim of the monograph is to present the most significant results concerning the developed prototype of the biomimetic Multi-Spiked Connecting Scaffold (MSC-Scaffold) fixing in the periarticular bone of the components of a new generation of entirely non-cemented resurfacing arthroplasty (RA) endoprostheses, obtained by our bioengineering team during the realization of two research projects of the Ministry of Science and Higher Education (Poland)/the National Science Centre Poland. Completed research tasks of these research projects concerned: design-ing the prototype biomimetic MSC-Scaffold for a new generation of non-cemented resurfacing arthroplasty endoprostheses, manufacturing of preprototypes of the MSC-Scaffold in the Selective Laser Melting (SLM) technology of powders of tita-nium alloys, bioengineering laboratory and numerical experiments and pilot experi-ments in an animal model.Chapter 1 describes the currently used cement-based hip joint resurfacing arthro-plasty endoprostheses in the background of previous designs of resurfacing endopros-theses. It also discusses the most common types of postoperative complications of this arthroplasty, caused by the method of fixation of the femoral component of modern resurfacing endoprostheses in the bone with the use of cement and a short stem.Chapter 2 presents the concept of an entirely non-cemented and stemless method of fixation of the components of resurfacing endoprostheses of the hip joint in the bone using the biomimetic MSC-Scaffold and the consequences of this innovative fixation method for the transfer of biomechanical loads in the implant-bone system.Chapter 3 presents the design, rapid prototyping, and manufacturing of the pro-totype biomimetic multi-spiked connecting scaffold (MSC-Scaffold) for a new generation of non-cemented resurfacing arthroplasty endoprostheses, including bio-engineering CAD design and modelling, methods and effects of the electrical dis-charge machining of the MSC-Scaffold spikes, stereolithography prototyping of the MSC-Scaffold spikes, prototyping and manufacturing of titanium alloy powders of the MSC-Scaffold preprototypes, and a prototype of the total hip resurfacing endo-prosthesis in the selective laser melting (SLM) technology, developed and carried out post-production treatment of the bone-contacting surface of the MSC-Scaffold preprototypes manufactured in the SLM technology, as well as reverse engineering the working prototype of partial resurfacing knee arthroplasty endoprosthesis manu-factured in the SLM technology for experimental implantations in an animal model.Chapter 4 presents the completed research task concerning the structural and osteoconductive functionalization of the interspike space of the prototype MSC-Scaffold. The theoretical basis for the evaluation of the pro-osteoconductive poten-tial of the MSC-Scaffold is provided. Results of evaluating the possibility of forming the structural-osteoconductive properties of the MSC-Scaffold are presented, as well as the course and results of the preliminary biological evaluation in cell culture of the MSC-Scaffold preprototypes after the structural-osteoconductive functionaliza-tion of their interspike space, with the course and results of the pilot study of the preprototypes of the structurally functionalized MSC-Scaffold in an animal model.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

571.4 UKL p

Penerbit

London : Taylor & Francis., 2024

Deskripsi Fisik

220 hlm

Bahasa

English

ISBN/ISSN

9781003364498

Klasifikasi

571.4

Tipe Isi

text

Tipe Media

computer

Tipe Pembawa

online resource

Edisi

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Subjek

Biophysics

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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