Ideal for all health care professionals who evaluate, diagnose, treat, or refer patients with endocrine disease or disorders, Manual of Endocrinology and Metabolism, Fifth Edition , brings together nearly 150 global authorities who share their knowledge and expertise on endocrine disorders in children, adolescents, and adults. Using a concise outline format, this thoroughly updated manual prese…
n the opening chapter of this book, we consider the history of the therapeutic use of levothyroxine (LT4). Recognition of the therapeutic value of LT4 emerged from experience gained from, essentially, empirical administration by physicians of crude thyroid extracts to people with advanced sequelae of hypothyroidism [1–4]. These clinical experiments arose from early studies of people w…