In a study of more than 60 substances chosen for their possible antikeratinogenic properties, Van Scott and Yu [1] found that the most effective drug belongs to the group of alpha-hydroxy acids. A three times a day application of citric, glycolic, lactic, malic, pyruvic and glucuronic acid, for instance, gave excellent results in all forms of ichthyosis except epidermolytic hyperkeratosis. The …